Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation

Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation

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High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA).A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell.A comparison of the sukrensi.com crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules.

Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2.5 bostik roll-cote GPa.No phase transition was observed up to this pressure.A reconstructive phase transition is required to induce conformational changes in the structure, which was confirmed by the results of crystallisation at high pressure.